Movie Gallery

Regionally specific levels and patterns of keratin 8 expression in the mouse embryo visceral endoderm emerge upon anterior-posterior axis determination

Despin-Guitard E, Quenec’Hdu R, Nahaboo W, Schwarz N, Leube RE, Chazaud C and Migeotte I

https://www.frontiersin.org/articles/10.3389/fcell.2022.1037041/full

Cortical tension regulates desmosomal morphogenesis

Moch M, Schieren J and Leube RE

https://www.frontiersin.org/articles/10.3389/fcell.2022.946190/full

A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics

Ratajczyk S, Drexler C, Windoffer R, Leube RE and Fuchs P

Cells 2022, 11, 3077. https://doi.org/10.3390/cells11193077

Combining Image Restoration and Traction Force Microscopy to Study Extracellular Matrix-Dependent Keratin Filament Network Plasticity

Yoon S, Windoffer R, Kozyrina AN, Piskova T, Di Russo J and Leube RE

https://www.frontiersin.org/articles/10.3389/fcell.2022.901038/full

Quantitative mapping of keratin networks in 3D

Windoffer R, Schwarz N, Yoon S, Piskova T, Scholkemper M, Stegmaier J, Bönsch A, Di Russo J, Leube RE

https://elifesciences.org/articles/75894

Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo

Nahaboo W , Eski SE , Despin-Guitard E, Vermeersch M, Versaevel M , Saykali B, Monteyne D, Gabriele S, Magin TM, Schwarz N , Leube RE, Zwijsen A, Perez-Morga D, Singh SP, Migeotte I

The EMBO Journal e108747 | 2022

Hemidesmosome-Related Keratin Filament Bundling and Nucleation

Moch M and Leube RE

Cellular and Molecular Life Sciences, (), 1-16, DOI 10.1007/s00018-019-03198-y

Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes

Bornes L, Windoffer R, Leube RE, Morgner J, van Rheenen J

https://www.life-science-alliance.org/content/4/1/e202000765

Growth, lifetime, directional movement and myosin‑dependent motility of mutant keratin granules in cultured cells

Lehmann SM, Leube RE, Windoffer R

Nature/Scientific Reports (2021)11:2379, doi.org/10.1038/s41598-021-81542-8

Regulation of keratin network dynamics by the mechanical properties of the environment in migrating cells

Pora A, Yoon S, Dreissen G, Hoffmann2 B, Merkel R, Windoffer R, Leube RE

Scientific Reports. (2020) 10:4574 | https://doi.org/10.1038/s41598-020-61242-5

Keratin intermediate filaments: intermediaries of epithelial cell Migration

Yoon S, Leube RE

https://www.sciencedirect.com/science/article/abs/pii/S0022202X19314460?via%3Dihub

Hemidesmosomes and focal adhesions treadmill as separate but linked entities during keratinocyte Migration

Pora A, Yoon S, Windoffer R, Leube RE

J Invest Dermatol. 2019 Sep;139(9):1876-1888, doi: 10.1016/j.jid.2019.03.1139

The keratin-desmosome scaffold: pivotal role of desmosomes for keratin Network morphogenesis

Moch M, Schwarz N, Windoffer R, Leube RE

Cellular and Molecular Life Sciences, (), 1-16, DOI 10.1007/s00018-019-03198-y

Threonine 150 phosphorylation of keratin 5 is linked to epidermolysis bullosa Simplex and regulates filament assembly and cell viability

Sawant M, Schwarz N, Windoffer R, Magin TM, Krieger J, Mücke N, Obara B, Jankowski V, Jankowski J, Wally V, Lettner T, Leube RE

https://www.sciencedirect.com/science/article/pii/S0022202X17330798

Intracellular Motility of Intermediate Filaments

Leube RE, Moch M, Windoffer R

http://cshperspectives.cshlp.org/content/9/6/a021980.full.pdf+html

Multidimensional Monitoring of Keratin Intermediate Filaments in Cultured Cells and Tissues

Schwarz N, Moch M, Windoffer R, Leube RE

http://www.sciencedirect.com/science/article/pii/S0076687915004528

Mechanical probing of the intermediate filament-rich C. elegans intestine

Jahnel O, Hoffmann B, Merkel R, Bossinger O, Leube RE

http://www.sciencedirect.com/science/article/pii/S0076687915004978

Dissection of keratin network formation, turnover and reorganization in living murine embryos

Schwarz N, Windoffer R, Magin TM, Leube RE, 2015.

http://www.nature.com/articles/srep09007

Keratin dynamics: modeling the interplay between turnover and transport

Portet S, Madzvamuse A, Chung A, Leube RE, Windoffer R

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121090

Intermediate filaments and the regulation of focal adhesion

Leube RE, Moch M, Windoffer R

http://www.sciencedirect.com/science/article/pii/S0955067414001227

Measuring the regulation of keratin filament network dynamics

Moch M, Herberich G, Aach T, Leube RE, Windoffer R

http://www.pnas.org/content/110/26/10664.long

Monitoring the cytoskeletal EGF response in live gastric carcinoma cells

Felkl M, Tomas K, Smid M, Mattes J, Windoffer R, Leube RE

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045280

Redistribution of adhering junctions in human endometrial epithelial cells during the implantation window of the menstrual cycle

Buck VU, Windoffer R, Leube RE, Classen-Linke I

http://link.springer.com/article/10.1007%2Fs00418-012-0929-0

Cytoskeleton in motion: The Dynamics of Keratin Intermediate Filaments in Epithelia

Windoffer R, Beil M, Magin TM, Leube RE

http://jcb.rupress.org/content/194/5/669.full

Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans

Abraham C, Bai L, Leube RE

http://www.sciencedirect.com/science/article/pii/S0306452211006634

“Panta rhei” Perpetual cycling of the keratin cytoskeleton

Leube RE, Moch M, Kölsch A, Windoffer R

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158631/

The keratin-filament cycle of assembly and disassembly

Kölsch A, Windoffer R, Würflinger T, Aach T, Leube RE

http://jcs.biologists.org/content/123/13/2266.long

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation

Löffek S, Wöll S, Höhfeld J, Leube RE, Has C, Bruckner-Tuderman L, Magin TM

http://onlinelibrary.wiley.com/doi/10.1002/humu.21222/abstract

Actin-dependent dynamics of keratin filament precursors

Kölsch A, Windoffer R, Leube RE

http://onlinelibrary.wiley.com/doi/10.1002/cm.20395/abstract

Intermediate Filaments in Caenorhabditis elegans

Carberry K, Wiesenfahrt T, Windoffer R, Bossinger O, Leube RE

http://onlinelibrary.wiley.com/doi/10.1002/cm.20372/abstract

Maintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2

Hüsken K, Wiesenfahrt T, Abraham C, Windoffer R, Bossinger O, Leube RE

http://www.sciencedirect.com/science/article/pii/S030146810960027X

p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells

Wöll S, Windoffer R, Leube RE

http://jcb.rupress.org/content/177/5/795.long

Focal adhesions are hotspots of keratin filament precursor formation

Windoffer R, Kölsch A, Wöll S, Leube RE

http://jcb.rupress.org/content/173/3/341.long

Dissection of keratin dynamics: different contributions of the actin and microtubule systems

Wöll S, Windoffer R, Leube RE

http://www.sciencedirect.com/science/article/pii/S0171933504000457

Imaging of keratin dynamics during the cell cycle and in response to phosphatase inhibition

Windoffer R, Leube RE

http://www.sciencedirect.com/science/article/pii/S0091679X04780127

Identification of novel principles of keratin filament network turnover in living cells

Windoffer R, Wöll S, Strnad P, Leube RE

http://www.molbiolcell.org/content/15/5/2436.long

Epidermolysis bullosa simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits

Werner NS, Windoffer R, Strnad P, Grund C, Leube RE, Magin TM

http://www.molbiolcell.org/content/15/3/990.long

Light-induced resistance of the keratin network to the filament-disrupting orthovanadate

Strnad P , Windoffer R and Leube RE

http://www.nature.com/jid/journal/v120/n2/full/5601731a.html

Induction of rapid and reversible cytokeratin filament network remodeling by inhibition

Strnad P, Windoffer R, Leube RE

http://jcs.biologists.org/content/115/21/4133.long

Desmosomes: interconnected calciumdependent structures of remarkable stability with significant integral membrane protein turnover

Windoffer R, Borchert-Stuhlträger M, Leube RE

http://jcs.biologists.org/content/115/8/1717.long

Tetraspan vesicle membrane proteins: synthesis, subcellular localization and functional properties

Hübner K, Windoffer R, Hutter H, Leube RE

http://www.sciencedirect.com/science/article/pii/S0074769602140046

De novo formation of cytokeratin filament networks originates from the cell cortex in A-431 cells

Windoffer R, Leube RE

http://onlinelibrary.wiley.com/doi/10.1002/cm.1039/abstract

In vivo detection of cytokeratin filament network breakdown in cells treated with the phosphatase

Strnad P, Windoffer R, Leube RE

http://link.springer.com/article/10.1007/s004410100455

Visualization of gap junction mobility in living cells

Windoffer R, Beile B, Leibold A, Thomas S, Wilhelm U, Leube RE

http://link.springer.com/article/10.1007/s004419900162

Detection of cytokeratin dynamics by time-lapse fluorescence microscopy in living cells

Windoffer R, Leube RE

http://jcs.biologists.org/content/112/24/4521.long