Sunday, September 5, 2021

Intermediate filaments during development and differentiation

Chairs: Thomas Magin / Nicole Schwarz

Walking Dinner

18:59 - 19:15

Jan Lammerding
Rudolf Leube
Pavel Strnad

A warm welcome from the organizing team

19:15 - 19:45

Isabelle Migeotte

Keratin dynamics govern the establishment of the maternal-fetal interface *

19:45 - 20:00

Thomas Dechat

The role of A-type lamins in bone development **

20:00 - 20:30

Didier Stainier

Cardiovascular development in zebrafish *

20:30 - 20:45

Hoda Moazzen

Identification of a novel function of desmoglein 2 as a suppressor of hematopoiesis in the embryonic mouse heart **

Informal get together

Monday, September 6, 2021

3D organization of intermediate filaments: Facilitators of cell and tissue morphology and function - Part 1

Chairs: Johannes Stegmaier / Paul Janmey

09:00-09:30

Sergei Strelkov

Some recent advances on intermediate filament structure and assembly *

09:30-09:45

Irene Istúriz

Engineering an artificial plectin to understand the interaction of actin and vimentin **

09:45-10:15

Ohad Medalia

Subnanometer structure of cellular vimentin filaments *

10:15-10:30

Reinhard Windoffer

Euclidean maps of cell type-specific keratin intermediate filament networks **

10:30-11:00

Mike Boxem

C. elegans BBLN-1 is essential for intermediate filament organization and apical membrane morphology *

Coffee

3D organization of intermediate filaments: Facilitators of cell and tissue morphology and function - Part 2

Chairs: Johannes Stegmaier / Paul Janmey

11:30-12:00

Roland Foisner

Lamins regulate chromatin organization and gene expression through diverse mechanisms *

12:00-12:15

Miriam Weber

Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy **

12:15-12:45

Kathleen Green

Desmosomes polarize mechanical signaling in the epidermis *

Lunch

Poster session 1

14:00-15:00

Flash talks - Part A
(Order will be announced at the conference.)

15:00-16:30

Poster discussion with coffee

Intermediate filament mechanics – Part 1

Chairs: Pierre Coulombe / Reinhard Windoffer

16:30-17:00

Sarah Köster

Unraveling the mechanics of vimentin networks *

17:00-17:15

Anna Schepers

Multiscale mechanics of reconstituted vimentin networks **

17:15-17:45

Jan Lammerding

Nuclear mechanobiology in 3D migration *

17:45-18:00

Paul Janmey

Vimentin intermediate filament networks are required for compression stiffening of cells and protection of nuclei from compressive stress **

Dinner

19:30-20:00

Michel Labouesse

Changing cell shape through ratchets *

20:00-20:15

Emma van Bodegraven

Intermediate filament heterogeneity and its role in the mechanics of glioblastoma invasion **

20:15-20:45

Dennis Discher

Stiff filament frustration on membranes of high Gaussian curvature - when, where, and why of nuclear rupture and associated DNA damage *

Informal get together

Tuesday, September 7, 2021

Intermediate filament as stress protectors – Part 1

Chairs: Diana Toivola / Sandrine Etienne-Manneville

09:00-09:30

John Connelly

Dissecting the role of the keratin cytoskeleton in nuclear mechanotransduction *

09:30-09:45

Matthias Rübsam

aPKC regulates keratin-dependent mechanical tissue resilience **

09:45-10:15

Rudolf Merkel   

Even intermediate filaments feel the strain *

10:15-10:30

Yeranuhi Hovhannisyan

Severe structural and mitochondrial dysfunctions caused by a heterozygous DES mutation in iPSC-derived cardiomyocytes **

10:30-11:00

Thomas Magin

Keratin isotypes regulate desmosome protein composition and adhesive strength *

Group Picture + Coffee

Intermediate filament as stress protectors – Part 2

Chairs: Diana Toivola / Sandrine Etienne-Manneville

11:45-12:15

John Eriksson

Intermediate filaments -The threads between cell signaling and cell architecture *

12:15-12:45

Pierre Coulombe

Intermediate filaments, response to stress, and adaptation *

Lunch

Poster session 2

14:00-15:00

Flash talks - Part B

(Order will be announced at the conference.)

15:00-16:30

Poster discussion

16:30-17:00

Poster prize and image awards

Break

Intermediate filaments as disease modulators - Part 1

Chairs: Kathleen Green / John Eriksson

17:15-17:30

Giulio Agnetti

Targeting desmin loss of and gain of toxic function in chronic and acute heart disease **

17:30-18:00

Pavel Strnad

Pathology of the keratin-desmosome scaffold in liver and gut *

18:00-18:30

Group Discussion

Methodology

18:30-19:00

Group Discussion

Future activities and networking

Dinner and Party

(20:00 – 21:30) Escape Game

Bajan Music with Victor Pribylov

Wednesday, September 8, 2021

Intermediate filaments as disease modulators – Part 2

Chairs: Kathleen Green / John Eriksson

09:00-09:30

Sandrine Etienne-Manneville

Role of intermediate filaments in glioblastoma cell invasion *

09:30-09:45

Martin Svoreň

Role of lamin-mediated nuclear deformability in cancer invasion and metastasis in vivo **

09:45-10:15

Elly Hol

Intermediate filaments in glioblastoma *

10:15-10:30

Florian Geisler

Intermediate filaments in C. elegans: From toxic aggregates to microbiome-dependent longevity **

10:30-11:00

Milos Pekny

Astrocyte intermediate filaments and the two-edged sword of reactive gliosis *

Coffee

Latest developments and upcoming challenges

Chairs: Jan Lammerding / Rudolf Leube / Thomas Magin / Rudolf Merkel / Johannes Stegmaier / Pavel Strnad

11:30-11:45

Diana Toivola

Colonic crypt keratins in tumor suppression and inflammatory bowel disease **

11:45-12:00

Leila Rato

Vimentin regulates cell growth through the mTORC1 signaling pathway **

12:00-12:30

All

Summing it all up and a peak into the future

Lunch